Zhaoxin Tang, Male, Born in Anhui Province, Ph.D. in Agriculture, Professor. He Received his Ph. at Northeast Agriculture University. Followed by 2 years of postdoctoral fellow and 1 year of postdoctoral fellow in University of Arkansas, USA, and 19 years of professor in South China Agriculture University.

          Zhaoxin Tang has been doing his resarch on Veterinary Internal Medicine and Diagnosis for more than 36 years. His research is currently focusing on mitochondrial medicine, clinical pathology,drug development, nutrition and metabolism diseases. He has published more than 30 SCI paers including Plos one, Toxicology Letters, Biometals, Biological Trace Element and Research at al.

Working Experience

July 2014~present:          Professor in clinical veterinary medicine. Supervisor in Master and Ph.D degree of clinical veterinary medicineSupervise the funds The Role of Mitophagy in Pathological Injury Induced by High Copper”（31572585）

April 2006 ~ June 2014  Deputy Dean of College of Veterinary Medicine, South China Agricultural University (SCAU)..Supervise the funds “Role of Copper on Mitochondrial Thioredoxin Metabolism in Broilers”（30871900）“Effects of Different type of Copper on Liver Mitochondrial functions and Metabolism in Broilers (30671550)” supported by Chinese Natural Science Foundation.

Dec,2002~March, 2006  Professor in Veterinary Clinical Medicine 

President of Animal Hospital in South China Agricultural University(SCAU), 

Head of  Department of Clinical Veterinary Medicine in SCAU. 

Supervise the funds “Pathogenesis of Changes of Mitochondrial Functions in Endotoxemia of Ruminants(30371068)” supported by Chinese Natural Science Foundation.

April,2002~ Nov.,2002  Postdoctoral research associate, Center of Excellence for Poultry Science, University of Arkansas, USA. Focused on researching the roles of ROS in health and diseases of poultry and mitochondrial dysfunction in pulmonary hypertension syndrome and association of mitochondrial function with feed efficiency in broilers. 

 Feb2001~March, 2002     Professor in Veterinary Clinical Medicine,  Advisor of Ph.D student in veterinary clinical medicine, Head of Department of Clinical Veterinary Medicine, College of Veterinary Medicine. President of Animal Hospital of South China Agricultural University. The Excellent Teacher of South China Agricultural University in 2001.Leading specialist in veterinary clinical medicine. Supervise the funds “Pathogenesis of Nitric Oxide in Endotoxemia of Goats(30070574)” supported by Chinese Natural Science Foundation.

 Feb,2000 ~ Feb,2001   Visiting associate professor, Center of Excellence for Poultry Science,

University of Arkansas,USA. Focused on mitochondrial dysfunction in pulmonary hypertension syndrome in broilers. Performed various analytical techniques associated with mitochondrial functions such as oxygen consumption, H2O2 measurement, complex activity and so on. 

 Feb,1998 ~ Jan,2000   Associate professor, Leader in veterinary clinical medicine, 

Department of Veterinary Pathophysiology, College of Veterinary Medicine, South China Agricultural University. Responsible for teaching veterinary clinical pathology and veterinary clinical diagnosis for graduate and undergraduate. Supervise the project “Effects of free radicals on pathogenesis of ascites in broiler” supported by Guangdong Natural Science Foundation

June,1995~Feb.,1998.  Postdoctoral researcher at Department of Veterinary Pathophysiology, College of Veterinary Medicine, Nanjing Agricultural University of China. The main project is to investigate pathways of oxygen free radical-mediated cell damage during endotoxic shock in goats. Supervised the projects “Mechanism of Biological Membrane damage Induced by Bacterial Endotoxin” granted by Chinese Postdoctoral Research Foundation, and “study on free radical pathogenesis in endotoxic shock” supported by Chinese Natural Science Foundation.

July,1988~Sept,1985  Assistant Professor of veterinary clinical pathology and small animal medicine, College of Veterinary Medicine, Anhui Agricultural University.  

                                      Instructed undergraduate students in hospital practice.

                                     Created all lecture and semester and final exam materials

July,1983~Sept,1985 Teaching assistant of veterinary clinical medicine in Anhui Agricultural University. Assisted and instructed undergraduate students in classroom and laboratory settings.

 Education

Ph.D., Veterinary Pathophysiology, College of Veterinary Medicine, Northeast Agricultural University of China. 1995

 DVM, College of Veterinary Medicine, Beijing Agricultural University of China. 1988

 Bachelor of Agronomy, College of Veterinary Medicine, Anhui Agricultural University of China. ,1983

Recent Publications

1．Yang F, Liao J, Pei R, Yu W, Han Q, Li Y, Guo J, Hu L, Pan J, Tang Z. Autophagy attenuates copper-induced mitochondrial dysfunction by regulating oxidative stress in chicken hepatocytes. Chemosphere. 2018, 204:36-43. 

2．Yang Fan, Pei Ruonan, Zhao Zhuowei, Liao Jainzhao, Yu Wenlan, Qiaona, Han Qingyue, Li Ying, Hu Lianmei, Guo Jianying, Pan Jianqiang, Tang Zhaoxin. Copper induces oxidative stress and apoptosis through mitochondria-neduated oatgwat ub cgucjeb geoaticttes, Toxiology In vitro, 2018, in print.

3．Kang Z, Qiao N, Tan Z, Tang Z, Li Y. Expression patterns and changes of the LCN2 gene in the testes of induced cryptorchidism and busulfan-treated mice. Syst Biol Reprod Med. 2017 , 63(6):364-369. 

4．Yang F, Cao H, Su R, Guo J, Li C, Pan J, Tang Z.Liver mitochondrial dysfunction and electron transport chain defect induced by high dietary copper in broilers. Poult Sci. 2017, 96(9):3298-3304. 

5．Hu L, Wang C, Zhang Q, Yan H, Li Y, Pan J, Tang Z. Mitochondrial Protein Profile in Mice with Low or Excessive Selenium Diets. Int J Mol Sci. 2016 , 17(7). : E1137. doi: 10.3390/ijms17071137.

6．Wang J, Chen J, Tang Z, Li Y, Hu L, Pan J. The Effects of Copper on Brain Microvascular Endothelial Cells and Claudin Via Apoptosis and Oxidative Stress. Biol Trace Elem Res. 2016, 174(1):132-141.

7．Su R, Cao H, Pan J, Li C, Chen Y, Tang Z. The Protective Roles of Selenium on Hepatic Tissue Ultrastructure and Mitochondrial Antioxidant Capacity in Copper-Overloaded Rats.Biol Trace Elem Res. 2015,167(1):110-114

8．Shi D, Liao S, Guo S, Li H, Yang M, Tang Z.  Protective effects of selenium on aflatoxin B1-induced mitochondrial permeability transition, DNA damage, and histological alterations in duckling liver. Biol Trace Elem Res. 2015 ,163(1-2):162-168

9．Liao S, Shi D, Clemons-Chevis CL, Guo S, Su R, Qiang P, Tang Z. Protective role of selenium on aflatoxin b1-induced hepatic dysfunction and apoptosis of liver in ducklings. Biol Trace Elem Res. 2014 ,162(1-3):296-301. 

10．Hu L, Yu W, Li Y, Prasad N, Tang Z. Antioxidant activity of extract and its major constituents from okra seed on rat hepatocytes injured by carbon tetrachloride. Biomed Res Int. 2014;2014:341291. 

11．Zhang Q, Chen L, Guo K, Zheng L, Liu B, Yu W, Guo C, Liu Z, Chen Y, Tang Z. Effects of different selenium levels on gene expression of a subset of selenoproteins and antioxidative capacity in mice. Biol Trace Elem Res. 2013 ,154(2):255-61

12．Yan C, Wang K, Chen L, He YM, Tang ZX. Effects of feeding an herbal preparation to sows on immunological performance of offspring. J Anim Sci. 2012, 90(11):3778-3782. (SCI=2.096)

13．Jia X, Chen L, Li J, Su R, Shi D, Tang Z.Effect of copper chloride exposure on the membrane potential and cytosolic free calcium in primary cultured chicken hepatocytes. Biol Trace Elem Res. 2012 , 148(3):331-5. （SCI=1.923）

14．Jin-Long Li,Hui-Xin Li, Xue-Jiao Gao, Jiu-Li Zhang, Shu Li, Shi-Wen Xu, Zhao-Xin Tang. Priority in Selenium Homeostasis Involves Regulation of SepSecS Transcription in the Chicken Brain. PLoS One，2012，7（4）：e35761 （SCI=4.411）

15．Xuexia Jia, Long Chen, Jingtao Li,Rongsheng Su, Dayou Shi & Zhaoxin Tang. Effect of Copper ured CChloride Exposure on the Membrane Potential and Cytosolic Free Calcium in Primary Culthicken Hepatocytes.Biol Trace Elem Res (2012) 148:331-335 SCI=1.923

16．Li JL, Li HX, Li S, Gao XJ, Xu SW, Tang ZX. Effects of Selenoprotein W gene expression by selenium involves regulation of mRNA stability in chicken embryos neurons.Biometals. 2012 SCI=2.823

17．Shining Guo, Dayou Shi, Shenquan Liao, Rongsheng Su, Yuanchao Lin, Jiaqiang Pan, Zhaoxin Tang. Influence of Selenium on Body Weights and Immune Organ Indexes in Ducklings Intoxicated with Aflatoxin B1 . Biological Trace Element Research , 2012, 146(2): 167-170 SCI=1.923

18．Dayou Shi, Shining Guo, Shenquan Liao, Rongsheng Su, Mingsheng Guo, Nian Liu, Pengfei Li, Zhaoxin Tang. Protection of Selenium on Hepatic Mitochondrial Respiratory Control Ratio and Respiratory Chain Complex Activities in Ducklings Intoxicated with Aflatoxin B1.  Biological Trace Element Research . 2012, 145(3) : 312-317 SCI=1.923

19．Dayou Shi, Shining Guo, Shenquan Liao, Rongsheng Su, Jiaqiang Pan, Yuanchao Lin, Zhaoxin Tang . Influence of Selenium on Hepatic Mitochondrial Antioxidant Capacity in Ducklings Intoxicated with Aflatoxin B1 . Biological Trace Element Research , 2012, 145(3) :  325-329 SCI=1.923

20．Guo SN ,Liao, SQ , Su, RS ,Lin, RQ , Chen, YZ , Tang, ZX , Wu, H ,Shi, DY , Influence of Longdan Xiegan Decoction on Body Weights and Immune Organ Indexes in Ducklings Intoxicated with Aflatoxin B-1 . JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2012, 11( 8) : 1162-1165  SCI=0.39

21．Shi, DY, Liao, SQ , Su, RS ,Lin, RQ , Guo SN, Lin, YC , Tang, ZX. Influence of Selenium on Hepatic Antioxidant Capacity in Ducklings Intoxicated with Afatoxin B-1. JOURNAL OF ANIMAL AND VETERINARY ADVANCES,  2012 , 11(7) : 1052-1055 SCI=0.39

22．Tang Z, Iqbal M, Cawthon D and Bottje W G. Heart and breast muscle mitochondrial dysfunction in pulmonary hypertension syndrome in broilers. Comparative Biochemistry and Physiology,2002, A132 : 527~540

23．Tang Z, Cawthon D and Bottje W G. Defects in heart and breast muscle mitochondrial electron transport of broilers with pulmonary hypertension syndrome. Free Rad Biol Med, 2000, 29:s25(abstract)

24．Iqbal M, Pumford NR, Tang ZX, Lassiter K, Ojano-Dirain C, Wing T, Cooper M, Bottje W. Compromised liver mitochondrial function and complex activity in low feed efficient broilers are associated with higher oxidative stress and differential protein expression.Poult Sci. 2005, 84(6):933-41. 

25．Iqbal M, Pumford N R, Tang Z, Lassiter K, Wing T, Cooper M, Bottje W. Low feed efficient boilers within a single genetic line exhibit higher oxidative stress and protein expression in breast muscle with lower mitochondrial complex activity. Poultry Science, 2004,83 : 474~484 

26．Bottje W, Tang Z X, Iqbal M, Cawthon D, Okimoto R, Wing T, Cooper M. Association of Mitochondrial function with feed efficiency within a single genetic line of male broilers. Poultry Science, 2002, 81: 546~555

27．Li JL, Li S, Tang ZX，Xu SW. Oxidative stress-mediated cytotoxicity of cadmium in chicken splenic lymphocytes. Toxicology Letters, 2010,196(S1):S122. （SCI 收录，IF 3.479）

28．Li JL, Gao R, Li S, Wang JT, Tang ZX, Xu SW. Testicular toxicity induced by dietary cadmium in cocks and ameliorative effect by selenium, Biometals. 2010,23(4):695-705. （SCI 收录，IF 3.172）

29．Jing Liua, Fengming Wu, Yuqing Liu, Tao Zhang and Zhaoxin Tang. The Effect of Melatonin on Mitochondrial Function in Endotoxemia Induced by Lipopolysaccharide. Asian-Aust. J. Anim. Sci，2011， 24（ 6 ）: 857 – 866

30．Li JL, Li HX, Li S, Jiang ZH, Xu SW, Tang ZX. Selenoprotein W Gene Expression in the Gastrointestinal Tract of Chicken is Affected by Dietary Selenium. BioMetals. 2010. DOI 10.1007/s10534-010-9395-0.（SCI 收录，IF 3.172）

31．Li JL, Ruan HF, Li HX, Li S, Xu SW, Tang ZX. Molecular cloning, characterization and mRNA expression analysis of a novel selenoprotein: avian selenoprotein W from chicken. Mol Biol Rep. 2010. DOI: 10.1007/s11033-010-0520-5.（SCI 收录，IF 2.038）

32．Rongsheng Su， Rongmei Wang ， Huabin Cao。Jiaqiang Pan，Lijun Chen，Chengmei Li Dayou Shi，Zhaoxin Tang. High Copper Levels Promotes Broiler Hepatocyte Mitochondrial Permeability Transition In Vivo and In Vitro. Biol Trace Elem Res，DOI 10.1007/s12011-011-9015-z

33．Rongsheng Su，Rongmei Wang， Shining Guo，Huabin Cao，Jiaqiang Pan，Chengmei Li，Dayou Shi，Zhaoxin Tang. In Vitro Effect of Copper Chloride Exposure on Reactive Oxygen Species Generation and Respiratory Chain Complex Activities of Mitochondria Isolated from Broiler LiverBiol Trace Elem Res，DOI 10.1007/s12011-011-9039-4

34．Gao H, Tan L Q, Tang Z X. Effects of Endotoxin on Phospholipid Metabolism and Fluidity of Liver Mitochondrial Membrane in Goats. Journal of Chinese athophysiology, 2000, 16(1):39~41

 Books were published and will be published in coming year.

1．Veterinary Internal Medicine, editor, textbook series for general higher agricultural University, China Science Publisher, 2011

2．Veterinary Clinical Diagnosis, 3rd ed. writer, Textbook Series for 21th Century of Chinese National Agricultural Universities in China. Published by Chinese Agriculture Press, 2001

3．Protocol of Veterinary Clinical Diagnosis, writer, Textbook Series for 21th Century of Chinese National Agricultural Universities in China. Published by Chinese Agriculture Press, 2001

4．Introduction to Animal Protection, writer, Textbook Series for 21th Century of Chinese National Universities in China. Published by Chinese High Education Press, 1999

5．Veterinary Clinical Differential Diagnosis, associate editor, Published by Chinese Forestry Press, 1996

6．Diseases in Small Animal, associate editor, Textbook Series for 21th Century of Chinese National Agricultural Universities in China. Publishing by Chinese Agricultural Press,2002 

7．Veterinary Internal Medicine, associate editor, Textbook Series for 21th Century of Chinese National Agricultural Universities in China. Publishing by Chinese Agricultural Press,2002 

8．Technique for Veterinary Clinical Therapy , Editor, Textbook Series for 21th Century of Chinese National Agricultural Universities in China. Publishing by Chinese Agricultural Press, 2002

9．Experimental Protocol of Veterinary Internal Medicine, Editor, Textbook Series for 21th Century of Chinese National Agricultural Universities in China. Publishing by Chinese Agricultural University Press,2006

10．Small Animal Internal Medicine, Editor, Textbook for undergraduate of Chinese Agricultural University, in press(2008) by Chinese Agricultural Scientific Press

11．Small Animal  Clinical Pathology, Editor, Textbook for undergraduate of Chinese Agricultural University, in press(2008) by Chinese Agricultural Scientific Press

Association

1．President of Society of Chinese Veterinary Internal Medicine in Mid-South Area, Chinese Association of Animal Husbandry and Veterinary Medicine, 2007

2．Associate President of Society of Chinese Small Animal Medicine, Chinese Association of Animal Husbandry and Veterinary Medicine, 2005

3．Associate President of Society of Chinese Veterinary Internal Medicine, Chinese Association of Animal Husbandry and Veterinary Medicine, 2006

4．Member of the standing committee: Chinese Association of Animal Science and Veterinary Medicine.2003

5．Council Member: Chinese Association of Veterinary Pathology and Physiology, 2002

 Accomplishments

1．Supervise the projects “Role of Copper on Mitochondrial Thioredoxin Metabolism in Broiler”(30871900)(2010~2012) supported by Chinese Natural Science Foundation.

2．Supervise the projects “Research on DNA vaccine for Canine Parvovirus” supported by DHN Animal Health Product Company Ltd.(2011~2012)

3．Supervise the projects “Isolation of Canine Parvovirus and Preparation of its Monoclonal antibody” supported by  DHN Animal Health Product Company Ltd.(2011~2012)

4．Supervise the projects “Pathogenesis of Changes of Mitochondrial Functions in Endotoxemia of Ruminants” (30371068) (2003~2006) supported by Chinese Natural Science Foundation.

5．Supervise the projects  “Effects of Different type of Copper on Liver Mitochondrial functions and Metabolism in Broilers” (30671550)(2007~2009)supported by Chinese Natural Science Foundation.

6．Supervise the projects “Pathogenesis of nitric oxide in endotoxemia of goats” (30070574)(2001-2003) supported by Chinese Natural Science Foundation.

7．Supervise the project “Studies on the Role of Oxygen Free Radicals in Microcirculatory Failure of Ruminants” supported by Chinese Natural Science Foundation from 1996 to 1998

8．Supervise the project “Mechanism of Biological Membrane damage induced by Bacterial Endotoxin” supported by the Chinese Postdoctoral Research Foundation from 1995 to 1997.

9．Supervise the project “Effects of free radicals on pathogenesis of ascites in broiler” supported by Guangdong Natural Science Foundation from 1998 to 2000. 

10．Participate in the project “Effects of Different Energy Diets on Heat Stress in Laying Hens” supported by Anhui Committee of Science and Technology from 1990 to 1995.

11．Awarded the 3rd prize of the advancement of science and technology by the Anhui Committee of Science and technology: for the research project Diarrhea syndrome of calves in Huihe river areas (1990)

12．Awarded the 3rd prize of the scientific thesis by the Ministry of Chinese National Agriculture, for the research project Effects of organogermanium and MD vaccination on oxygen free radical metabolism in vMDV-infected chickens (1996)

13．Awarded the 2nd prize of the advancement of science and technology by the Anhui Committee of Science and technology for the project Effects of Different Energy Diets on Heat Stress in Laying Hens (1996)

14．Awarded the 2nd  prize of advancement of science and technology by Yunan Province Government, 2006