Resume:

Youzhi Tang，Male，Born in Hubei province, Ph.D. in Philosophy, Associate Professor. He received his Ph.D Degree in 2009 at Jilin University. Followed by 4 years of assistant professor at South China Agricultural University. He was promoted to associate professor in 2013 and was hired out as Young professor at South China Agricultural University in 2017. 

Youzhi Tang has been doing his research in medicinal chemistry for more than fourteen years. His research is currently focusing on design, synthesis, bioactivity evaluation of drugs including antibacterials, antioxidants as well as aintiinflammation agents. He has published more than 20 SCI papers including EJMC, JACS and CBDD, which have been cited more than 300 times. 

Education and Training Program: 

May, 2014-September, 2015: Visiting Scholar in DeGrado Lab, Department of Pharmaceutical Chemistry, University of California San Francisco, CA, USA

June, 2009: Received Ph.D. degree, Organic Chemistry, College of Chemistry, Jilin University, Changchun, China

June, 2004: Received Bachelor degree, Polymer Material, College of Chemistry, Jilin University, Changchun, China

Working Experience:

Feb, 2017-Up to now: Young Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

Apr, 2017-Dec, 2017: Project Specialist, National Natural Science Foundation of China, Beijing, China

Dec, 2013-Feb, 2017: Associate Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

Dec, 2013-July, 2009: Assistant Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

Research Interests:

Design, synthesis and bioactivity evaluation of antibacterials, antioxidants as well as antiinflammation agents.

Grants: 

Design, synthesis and mechanisms of New Delhi Metallo-β-lactamase 1 inhibitors, the National Natural Science Foundation, 2017-2020, 620,000 RMB, grant No: 31672602.

Study on the detection and control technology of important pathogens in livestock and poultry, the National Key R&D Program of China, 2016-2020, 520,000 RMB, grant No: 2016YFD0501307.

Publications:

After independent research:

[1]Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang* “Synthesis and antibacterial activities of novel pleuromutilin derivatives bearing an aminothiophenol moiety” Chemical Biology & Drug Design, 2018, 92: 1627-1637. (DOI: 10.1111/cbdd.13328)

[2]Zhao-Sheng Zhang#, Yun-Zhen Huang#, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu, You-Zhi Tang* “Synthesis and antibacterial activity against MRSA of pleuromutilin derivatives possessing a mercaptoethylamine linker” Medicinal Chemistry, 2018, 14(6): 585-594. (DOI:10.2174/1573406414666180416131737)

[3]Shao-Qing Zhang, Marco Chino, Lijun Liu, Youzhi Tang, Xiaozhen Hu, William F. DeGrado*, Angela Lombardi* “De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles” J. Am. Chem. Soc., 2018, 140 (4): 1294–1304. (DOI: 10.1021/jacs.7b08261)

[4]Zhen Jin, Yao-Zhi Yang, Jian-Xin Chen*, You-Zhi Tang* “Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-Hydroxyflavone and 7,8-Dihydroxyflavone” Journal of Pharmacy and Pharmacology, 2017, 69(7): 865-871. (DOI: 10.1111/jphp.12714) 

[5]Mei-Ling Gao, Jie Zeng, Xi Fang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang* “Design, synthesis and antibacterial evaluation of novel pleuromutilin derivatives possessing piperazine linker” European Journal of Medicinal Chemistry, 2017, 127: 286-295. (DOI: 10.1016/j.ejmech.2017.01.004)

[6]Nilgun Isik Reed, You-Zhi Tang, Joel McIntosh, Yibing Wu, Kathleen S. Molnar, Annafelicia Civitavecchia, Dean Sheppard, William F. DeGrado, Hyunil Jo “Exploring N-Arylsulfonyl-l-proline Scaffold as a Platform for Potent and Selective αvβ1 Integrin Inhibitors” ACS Med. Chem. Lett., 2016, 7(10): 902-907. (DOI: 10.1021/acsmedchemlett.6b00196).

[7]Jian Luo, Qiu-E Yang, Yuan-Yuan Yang, You-Zhi Tang*, Ya-Hong Liu* “Design, synthesis and structure-activity relationship studies of novel pleuromutilin derivatives having a piperazine ring” Chemical Biology & Drug Design, 2016, 88(5): 699-709. (DOI: 10.1111/cbdd.12799).

[8]Yao-Zhi Yang, You-Zhi Tang*, Ya-Hong Liu* “Wogonoside displays anti-inflammatory effects through modulating inflammatory mediator expression using RAW264.7 cells” Journal of Ethnopharmacology, 148(1): 271-276, 2013.

[9]You-Zhi Tang*, Jian Luo, Xiaojie Chen, Bo Wang, Xiangguang Shen, Jianhua Liu* “Synthesis and in vitro antibacterial activity of four novel pleuromutilin derivatives” Journal of The Chilean Chemical Society, 58(1): 1537-1540, 2013.

[10]You-Zhi Tang*, Ya-Hong Liu*, Jian-Xin Chen “Pleuromutilin and its derivatives-The lead compounds for novel antibiotics” Mini Reviews in Medicinal Chemistry,  12(1)，53-61, 2012.

[11]Li-Guo Yuan, You-Zhi Tang, Y-X Zhang, Jian Sun, Xian-Yang Luo, Li-Xiang Zhu, Zhan Zhang, Rui Wang, Ya-Hong Liu*. “Dosage assessment of valnemulin in pigs based on population pharmacokinetic and Monte Carlo simulation” Journal of Veterinary Pharmacology and Therapeutics 2015:38 (4); 400-409.

[12]Yun-Yun Yang, You-Zhi Tang, Chun-Lin Fan, Hui-Tai Luo, Peng-Ran Guo, Jian-Xin Chen “Identification and determination of the saikosaponins in Radix bupleuri by accelerated solvent extraction combined with rapid-resolution LC-MS” Journal of Separation Science, 33(13), 1933-1945, 2010.

[13]Dong-Ping Zeng, Xiang-Guang Shen, Li-Min He, Huan-Zhong Ding, You-Zhi Tang, Yong-Xue Sun, Bing-Hu Fang, Zhen-Ling Zeng “Liquid chromatography tandem mass spectrometry for the simultaneous determination of mequindox and its metabolites in porcine tissues” Journal of Separation Science, 35(10-11), 1327-1335, 2012.

[14]Tang Youzhi，Liu Yahong，Zhang Zhaosheng. Pleuromutilin Derivative Having 2-Amino Phenyl Mercaptan Side Chain, Preparation Method Therefor, And Uses Thereof. 2018, PCT Int. Appl., WO2018058534.

[15]DeGrado William F.; Sheppard Dean; Jo Hyunil; Reed Nilgun Isik; Tang Youzhi; Mcintosh, Joel. Anti-alphavbeta1 integrin inhibitorss and methods of use. 2016, PCT Int. Appl., WO2016145258

[16]DeGrado William F.; Sheppard Dean; Jo Hyunil; Reed Nilgun Isik; Tang Youzhi. Anti-alphavbeta1 integrin compounds and methods. 2014, PCT Int. Appl., WO2015048819

Before independent research:

[1]You-Zhi Tang, Zai-Qun Liu* “Diclofenac acid: A Free-radical-scavenger in Protecting DNA against Radical-induced Oxidative Damage” Drug Dev. Res., 2009, 70, 520-524. 0

[2]You-Zhi Tang, Zai-Qun Liu*, Di Wu “Lidocaine: An Inhibitor in the Free-radical-induced Hemolysis of Erythrocytes” J. Biochem. Mol. Toxicol., 2009: 23; 81-86. 2

[3]You-Zhi Tang, Zai-Qun Liu* “Chemical Kinetic Behavior of Chlorogenic Acid in Protecting Erythrocyte and DNA against Radical-induced Oxidation” J. Agric. Food Chem., 2008: 56; 11025-11029. 5

[4]You-Zhi Tang, Zai-qun Liu* Quantitative structure-activity relationship of hydroxyl-substituent Schiff bases in radical-induced hemolysis of human erythrocytes” Cell Biochem. Funct., 2008: 26; 185-191. 0

[5]You-Zhi Tang, Zai-Qun Liu* “The antioxidant effect of hydroxyl-substituent Schiff bases on the free-radical-induced hemolysis of human erythrocytes” Cell Biochem. Funct., 2007: 25; 149-158. 0

[6]You-Zhi Tang, Zai-Qun Liu* “Insight into the free-radical-scavenging mechanism of hydroxyl-substituent Schiff bases in the free-radical-induced hemolysis of erythrocytes”   Cell Biochem. Funct., 2007: 25; 701-710. 0

[7]You-Zhi Tang, Zai-Qun Liu* “Free-radical-scavenging effect of carbazole derivatives on AAPH-induced hemolysis ofhuman erythrocytes” Bioorg. Med. Chem., 2007: 15; 1903-1913. 9

[8]You-Zhi Tang, Zai-Qun Liu* “Free-radical-scavenging effect of carbazole derivatives on DPPH and ABTS radicals” J. Am. Oil Chem. Soc., 2007: 84; 1095-1100. 5

[9]You-Zhi Tang, Zai-Qun Liu* “Evaluation of the free-radical-scavenging activity of diclofenac acid on the free-radical-induced hemolysis of human erythrocytes” J. Pharm. Pharmacol., 2006: 58; 625-631. 4

[10]Zai-Qun Liu*, You-Zhi Tang, Di Wu “Antioxidant Effects of Phenothiazine, Phenoxazine and Iminostilbene on Free-radical-induced Oxidation of Linoleic Acid and DNA” J. Phys. Org. Chem. 2009: 22; 1009-1014. 0

[11]Guo-Xiang Li, You-Zhi Tang, Zai-Qun Liu* “Prooxidant Effects of Phenothiazine and Phenoxazine on Erythrocytes in the Presence of Peroxyl Radical” J. Biochem. Mol. Toxicol., 2009: 23; 280-286. 1

[12]Guo-Xiang Li, You-Zhi Tang, Zai-Qun Liu* “The “double-faced” effect of VC-12 on free-radical-induced hemolysis of human erythrocytes: antioxidant and prooxidant” 

J. Pharm. Pharmacol., 2007: 59; 739-743. 0

[13]Feng Zhao, You-Zhi Tang, Zai-Qun Liu* “The protective effect of icariin on DNA against radical-induced oxidative damage” J. Pharm. Pharmacol., 2007: 59; 1729-1732. 9