Resume:

Ji-Long Liu is a bioinformatician with training in reproductive biology, evolutionary biology and computational biology from Northeast Agricultural University, China. His academic career started at Shantou University in 2011. In 2013, he moved to College of Veterinary Medicine, South China Agricultural University. Dr. Liu's research interest is the molecular mechanisms underlying embryo implantation into the uterus. In particular his lab is focusing on developing bioinformatics tools for reproductive biology. 

Education and Training Program: 

2018-present Young Professor, College of Veterinary Medicine, South China Agricultural University, China

2013-2018 Lecture, College of Veterinary Medicine, South China Agricultural University, China

2011-2013 Lecture, Department of biology, Shantou University, China

2002-2011 Bachelor/Master/Ph.D., College of Life Sciences, Northeast Agricultural University, China

Research Interests:

The molecular mechanisms underlying embryo implantation into the uterus; Machine learning approaches; Big data mining; Evolution of embryo implantation; Database construction for reproductive biology; Reproduction-related diseases.

Grants: 

National Natural Science Foundation of China Grants 31771665 and 31271602 

Publications (*, corresponding author):

1Zhang WQ, Zhao M, Huang MY, Liu JL(*): Comparative Transcriptomic Analysis of Embryo Implantation in Mice and Rats. Cell Physiol Biochem 2018;50:668-678. (IF=5.5)

2Wei C, Guo D, Li Y, Zhang K, Liang G, Li Y, Ma Y, Liu J(*), Li Y(*): Profiling analysis of 17beta-estradiol-regulated lncRNAs in mouse thymic epithelial cells. Physiol Genomics 2018;50:553-562.

3Liu JL(*), Zhao M, Zhang WQ, Huang MY: Expansion of the IL1B gene family in the pig. Proc Natl Acad Sci U S A 2018;115:E5843-E5844. (IF=9.504, letter)

4Liu JL(*), Zhang WQ, Huang MY: Transcriptional signature of the decidua in preeclampsia. Proc Natl Acad Sci U S A 2018;115:E5434-E5436. (IF=9.504, letter)

5Liu JL(*): Implantation in eutherians: Which came first, the inflammatory reaction or attachment? Proc Natl Acad Sci U S A 2018;115:E1-E2. (IF=9.504, letter)

6Huang MY, Zhang WQ, Zhao M, Zhu C, He JP, Liu JL(*): Assessment of Embryo-Induced Transcriptomic Changes in Hamster Uterus Using RNA-Seq. Cell Physiol Biochem 2018;46:1868-1878. (IF=5.5)

7Huang MY, Liu JL(*): Transcription start sites at the end of protein-coding genes. Hum Genomics 2018;12:15.

8Zhao M, Zhang WQ, Liu JL(*): A study on regional differences in decidualization of the mouse uterus. Reproduction 2017;153:645-653.

9Zhang H, Liu J (co-first author), Tai Y, Zhang X, Zhang J, Liu S, Lv J, Liu Z, Kong Q: Identification and characterization of L1-specific endo-siRNAs essential for early embryonic development in pig. Oncotarget 2017;8:23167-23176.

10Liu JL(*), Zhang WQ, Zhao M, Huang MY: Integration of Transcriptomic and Metabolomic Data Reveals Enhanced Steroid Hormone Biosynthesis in Mouse Uterus During Decidualization. Proteomics 2017;17 (IF=4.1)

11Liu JL(*), Zhang WQ, Huang MY: Transcription start site-associated small RNAs in the PTEN gene. Proc Natl Acad Sci U S A 2017;10.1073/pnas.1718027114 (IF=9.504, letter)

12Li Y, Kang ZL, Qiao N, Hu LM, Ma YJ, Liang XH, Liu JL, Yang ZM: Effects of Excess Copper Ions on Decidualization of Human Endometrial Stromal Cells. Biol Trace Elem Res 2017;177:10-15.

13Liu JL(*), Zuo RJ, Peng Y, Fu YS: The Impact of Multiparity on Uterine Gene Expression and Decidualization in Mice. Reprod Sci 2016;23:687-694.

14Liu JL(*), Zhao M, Peng Y, Fu YS: Identification of gene expression changes in rabbit uterus during embryo implantation. Genomics 2016;107:216-221.

15Liu JL(*), Zhao M: Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis. Int J Mol Sci 2016;17:

16Liu JL(*), Zhao M: A PubMed-wide study of endometriosis. Genomics 2016;108:151-157.

17Liu JL(*), Wang TS, Zhao M: Genome-Wide Association Mapping for Female Infertility in Inbred Mice. G3 (Bethesda) 2016;6:2929-2935.

18Liang XH, Deng WB, Liu YF, Liang YX, Fan ZM, Gu XW, Liu JL, Sha AG, Diao HL, Yang ZM: Non-coding RNA LINC00473 mediates decidualization of human endometrial stromal cells in response to cAMP signaling. Sci Rep 2016;6:22744.

19Guo D, Ye Y, Qi J, Zhang L, Xu L, Tan X, Yu X, Liu Q, Liu J, Zhang Y, Ma Y, Li Y: MicroRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-beta signaling. Acta Biochim Biophys Sin (Shanghai) 2016;48:840-849.

20Zuo RJ, Gu XW, Qi QR, Wang TS, Zhao XY, Liu JL, Yang ZM: Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy. J Biol Chem 2015;290:21280-21291.

21Wang TS, Gao F, Qi QR, Qin FN, Zuo RJ, Li ZL, Liu JL, Yang ZM: Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model. Biol Open 2015;4:893-902.

22Qi QR, Zhao XY, Zuo RJ, Wang TS, Gu XW, Liu JL, Yang ZM: Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization. Cell Cycle 2015;14:1842-1858.

23Liu JL(*), Wang TS, Zhao M, Peng Y, Fu YS: A Transcriptomic Study of Maternal Thyroid Adaptation to Pregnancy in Rats. Int J Mol Sci 2015;16:27339-27349.

24Liu JL(*), Wang TS: Systematic Analysis of the Molecular Mechanism Underlying Decidualization Using a Text Mining Approach. PLoS One 2015;10:e0134585.

25Liu JL(*), Peng Y, Fu YS: Efficient prediction of progesterone receptor interactome using a support vector machine model. Int J Mol Sci 2015;16:4774-4785.

26Deng WB, Liang XH, Liu JL, Yang ZM: Regulation and function of deiodinases during decidualization in female mice. Endocrinology 2014;155:2704-2717.

27Chen K, Zhu C, Cai M, Fu D, Cheng B, Cai Z, Li G, Liu J: Integrative metabolome and transcriptome profiling reveals discordant glycolysis process between osteosarcoma and normal osteoblastic cells. J Cancer Res Clin Oncol 2014;140:1715-1721.

28Shi Z, Zhang J, Qian X, Han L, Zhang K, Chen L, Liu J, Ren Y, Yang M, Zhang A, Pu P, Kang C: AC1MMYR2, an inhibitor of dicer-mediated biogenesis of Oncomir miR-21, reverses epithelial-mesenchymal transition and suppresses tumor growth and progression. Cancer Res 2013;73:5519-5531.

29Su RW, Jia B, Ni H, Lei W, Yue SL, Feng XH, Deng WB, Liu JL, Zhao ZA, Wang TS, Yang ZM: Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF. PLoS One 2012;7:e34325.

30Liu JL, Liang XH, Su RW, Lei W, Jia B, Feng XH, Li ZX, Yang ZM: Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey. J Biol Chem 2012;287:13899-13910.

31Lei W, Feng XH, Deng WB, Ni H, Zhang ZR, Jia B, Yang XL, Wang TS, Liu JL, Su RW, Liang XH, Qi QR, Yang ZM: Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice. J Biol Chem 2012;287:15174-15192.

32Sha AG, Liu JL(co-first author), Jiang XM, Ren JZ, Ma CH, Lei W, Su RW, Yang ZM: Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing. Fertil Steril 2011;96:150-155.e155.

33Liu JL, Yang ZM: Non-coding RNAs and embryo implantation. Front Biosci (Elite Ed) 2011;3:1092-1099.

34Liu JL, Su RW, Yang ZM: Differential expression profiles of mRNAs, miRNAs and proteins during embryo implantation. Front Biosci (Schol Ed) 2011;3:1511-1519.

35Yue X, Lan F, Yang W, Yang Y, Han L, Zhang A, Liu J, Zeng H, Jiang T, Pu P, Kang C: Interruption of beta-catenin suppresses the EGFR pathway by blocking multiple oncogenic targets in human glioma cells. Brain Res 2010;1366:27-37.

36Su RW, Lei W, Liu JL, Zhang ZR, Jia B, Feng XH, Ren G, Hu SJ, Yang ZM: The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation. PLoS One 2010;5:e15513.

37Li G, Zhang W, Zeng H, Chen L, Wang W, Liu J, Zhang Z, Cai Z: An integrative multi-platform analysis for discovering biomarkers of osteosarcoma. BMC Cancer 2009;9:150.

38Zhao YC, Chi YJ, Yu YS, Liu JL, Su RW, Ma XH, Shan CH, Yang ZM: Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period. Endocrinology 2008;149:2325-2332.

39Hu SJ, Ren G, Liu JL, Zhao ZA, Yu YS, Su RW, Ma XH, Ni H, Lei W, Yang ZM: MicroRNA expression and regulation in mouse uterus during embryo implantation. J Biol Chem 2008;283:23473-23484.

40Ma XH, Hu SJ, Ni H, Zhao YC, Tian Z, Liu JL, Ren G, Liang XH, Yu H, Wan P, Yang ZM: Serial analysis of gene expression in mouse uterus at the implantation site. J Biol Chem 2006;281:9351-9360.

To Students :

　　Education is not the filling of a vessel, but the kinding of a flame. --Socrates