Resume:

Li Yugu, male, PhD, professor and doctoral supervisor, was born in Pingxiang, Jiangxi province in August 1963. He graduated from Jiangxi Agricultural University in 1984 with a bachelor's degree in veterinary medicine, Guangxi Agricultural University in 1987 with a master's degree in animal histology and embryology, and South China Agricultural University in 2005 with a doctor's degree in veterinary pathology. He began to work in Department of Animal Science and Veterinary Medicine, Jiangxi Agricultural University in August 1987 and transferred to College of Veterinary Medicine, South China Agricultural University in August 1993. He has being engaged in teaching and scientific research in animal histology and embryology. He was promoted to associate professor in 1997, promoted to professor in 2002 and qualified as a doctoral supervisor in 2005. He presided over and participated in more than 20 scientific research projects, published more than 100 research papers, textbooks and monographs, won one“Jiangxi Science and Technology Progress Award (First Grade)” in 1997 and one “Guangdong Science and Technology Progress Award (Third Grade)” in 2007.

Education:

2002.09~2005.06, PhD, College of Veterinary Medicine, South China Agricultural University

1984.09~1987.07, Master, Department of Animal Science and Veterinary Medicine, Guangxi Agricultural University

1980.09~1984.07, Bachelor, Department of Animal Science and Veterinary Medicine, Jiangxi Agricultural University

Working Experiences:

From 2002.12, Professor, PhD Supervisor, College of Veterinary Medicine, South China Agricultural University

1997.12~2002.11, Associate Professor, Master Tutor, Department of Veterinary Medicine, South China Agricultural University

1993.08~1997.11, Lecturer, Department of Veterinary Medicine, South China Agricultural University

1991.01~1993.08, Lecturer, Department of Animal Science and Veterinary Medicine, Jiangxi Agricultural University

1987.08~1990.12, Assistant, Department of Animal Science and Veterinary Medicine, Jiangxi Agricultural University 

Research Interests:

Molecular mechanisms of development, involution and regeneration of thymus in animals

Morphology of animal immune neuroendocrine network

Projects and Grants:

1.The roles of microRNAs in sexually dimorphic thymus involution and their target gene regulatory network, National Natural Science Foundation of China (31572475), 2016.01~2019.12

2.Molecular mechanism involved in Ghrelin suppressing thymic adipogenesis, National Natural Science Foundation of China (31272519), 2013.01~2016.12

3.Regenerative effect of Ghrelin on atrophied thymus and its molecular mechanism in mice, National Natural Science Foundation of China (30871834), 2009.01~2011.12

4.Reversal effect of Ghrelin on estrogen-induced thymus atrophy and its molecular  mechanism in mice, University Doctoral Research Fund Project, Ministry of Education (20094404110015), 2010.01~2012.12

5.Histopathological study of H5N1 subtype highly pathogenic avian influenza, Guangdong Provincial Science and Technology Research Project(2004A2090102) Subproject, 2004.01~2006.12

6.Histological study of the immunoendocrine system of rhesus monkeys and beagle dogs, National Science and Technology Research Project(96A230606) Subproject, 1997.01~2001.12

Publications:

Papers:

1.Li Yugu, Ye Zhenbang. Development and T cell distribution of bursa Fabricius and thymus in Guangxi yellow chickens[J]. Journal of Guangxi Agricultural University, 1990, 9(2): 46-52.

2.Li Yugu, Zeng Wenzong. The heterogeneity of mast cells in chicken lymphoid organs[J]. Journal of Guangxi Agricultural University, 1997, 16(1): 25-30. 

3.Li Yugu, Huang Xingxu, Li Chuxuan, Chen Yuanyin. The heterogeneity of mast cells in duck lymphoid organs[J]. Journal of South China Agricultural University, 1997, 18(3): 110-115.

4.Li Yugu, Li Chuxuan, Xin Chaoan. Ultrastructure of mast cells in chicken thymus[J]. Chinese Journal of Veterinary Science and Technology,1999, 29(6):33-35. 

5.Li Yugu, Xin Chaoan, Li Chuxuan, Chen Yuanyin, Liu Jinquan. Ultrastructure of APUD-like cells in goose thymus[J]. Chinese Journal of Veterinary Sciences, 1999, 19(2): 178-181.

6.Li Yugu, Xin Chaoan, Li Chuxuan. Ultrastructure of APUD-like cells in chicken thymus[J]. Journal of South China Agricultural University, 1999, 20(4): 33-37.

7.Li Yugu, Li Chuxuan, Chen Yuanyin, Liu Jinquan. Ultrastructure of mast cells in goose thymus[J]. Journal of South China Agricultural University, 1999, 20(1): 41-44. 

8.Li Yugu, Xin Chaoan, Li Chuxuan, Lun Xuan. Electron microscopic observation of  apoptosis of thymocytes in duck thymus[J]. Chinese Journal of Animal and Veterinary Sciences, 2000, 31 (6): 571-575 . 

9.Li Yugu, Xin Chaoan. Electron microscopic observation of apoptosis of thymocytes in goose thymus[J]. Chinese Journal of Veterinary Science and Technology, 2001, 31(12): 35-38.

10.Li Yugu, Zhang Yuan, Huang Ren, Cheng Shujun. Histochemistry and ultrastructure of mast cells in rhesus monkeys[J]. Journal of South China Agricultural University, 2002, 22(2): 74-76. 

11.Li Yugu, Zhang Yuan, Kong Xiaoming, Huang Ren, Cheng Shujun. Ultrastructural study on heterogeneity of thymic epithelial cells in rhesus monkeys[J]. Chinese Journal of Animal and Veterinary Sciences, 2002, 33(6): 570-572. 

12.Li Yugu, Zhang Yuan, Lun Xuan, Li Chuxuan, Huang Ren, Cheng Shujun. Ultrastructure of chromophilic cells in adrenal medulla of rhesus monkeys[J].Chinese Journal of Veterinary Sciences, 2002, 21 (3): 253-255.

13.Li Yugu, Zhang Yuan, Huang Ren, Cheng Shujun. Ultrastructure of mast cells in Neurohypophysis of Beagle dogs[J]. Chinese Journal of Veterinary Science and Technology, 2002, 32(3): 7-8. 

14.Li Yugu, Zhang Yuan, Zhong Yimin, Li Chuxuan, Huang Ren, Cheng Shujun. Ultrastructural observation of the pars distalis of adenohypophysis in rhesus monkeys[J]. Chinese Journal of Veterinary Sciences, 2002, 22(1): 56-58. 

15.Zhang Yuan, Li Yugu*, Cheng Shujun, Huang Ren. Microstructure and ultrastructure of thymus in rhesus monkeys[J]. Journal of South China Agricultural University, 2002, 23(1): 71-74.

16.Zhang Yuan, Li Yugu*, Huang Ren, Cheng Shujun. Microstructure of lymph nodes in rhesus monkeys[J]. Journal of South China Agricultural University, 2002, 23(3): 74-77. 

17.Li Yugu, Zhang Yuan, Cheng Shujun, Huang Ren, Kong Xiaoming, Wang Pingli. Endocrine-like cells in neurohypophysis of beagle dogs[J]. Journal of South China Agricultural University, 2003, 24(4): 113-115. 

18.Li Yugu, Zhang Yuan, Cheng Shujun, Huang Ren. Microstructure and ultrastructure of adrenal cortex in rhesus monkeys[J]. Chinese Journal of Veterinary Sciences, 2003, 22(1): 177-179. 

19.Li Yugu, Zhang Yuan, Kong Xiaoming, Cheng Shujun, Huang Ren. Ultrastructure of the pars distalis of adenohypophysis in beagle dogs[J]. Chinese Journal of Animal and Veterinary Sciences, 2003, 34(5): 468-470.

20.Li Yugu, Zhang Yuan, Kong Xiaoming, Cheng Shujun, Huang Ren. Electron microscopic observation of chromaffin cells of adrenal medulla in beagle dogs[J]. Chinese Journal of Veterinary Science and Technology, 2003, 33(3): 62-64.

21.Li Yugu, Zhang Yuan, Cheng Shujun, Kong Xiaoming, Huang Ren, Wang Pingli. Ultrastructure of the pars tuberalis of adenohypophysis in beagle dogs[J]. Journal of South China Agricultural University, 2004, 25(1): 115-117.

22.Zhang Yuan, Li Yugu*, Cheng Shujun, Huang Ren, Li Chuxuan. Histology of thyroid and parathyroid gland in rhesus monkeys[J]. Chinese Veterinary Sciences, 2006, 36(2): 131-134.

23.Li Yugu, Zhang Yuan, Cheng Shujun, Huang Ren, Li Chuxuan. Microstructure and ultrastructure of thyroid gland in beagle dogs[J]. Chinese Veterinary Sciences, 2006, 36(3): 230-233.

24.Li Yugu, Zhou Quanhe, Cui Congying, Ye Yuanlan, Ma Yongjiang, Zhang Yuan, Li Chuxuan. Histopathology of ducks experimentally infected with a highly pathogenic avian influenza virus, A/duck/Guangdong/220/2004(H5N1)[J]. Chinese Journal of Animal and Veterinary Sciences, 2008, 39 (10): 1373-1381. 

25.Li Yugu, Ye Yuanlan, Cui Congying, Zhou Quanhe, Zhang Yuan, Ma Yongjiang, Li Chuxuan. Induction of apoptosis by a highly pathogenic avian influenza virus, A/duck/Guangdong/220/2004(H5N1) in experimentally infected ducks[J]. Chinese Journal of Animal and Veterinary Sciences, 2009, 40 (7): 1069-1073. 

26.Li Yugu, Ye Yuanlan, Zhou Quanhe, Cui Congying, Zhang Yuan, Ma Yongjiang, Li Chuxuan. Localization of a highly pathogenic avian influenza virus, A/duck/Guangdong/220/2004(H5N1) in experimentally infected ducks[J]. Chinese Journal of Animal and Veterinary Sciences, 2009, 40( 8): 1202-1208. 

27.Wei Fengmei, Li Yugu*, Ye Yuanlan, Zhang Yuan, Ma Yongjiang, Jiang Qingyan. Localization and development of Ghrelin-immunopositive cells in peripheral organs of broiler chickens[J]. Chinese Journal of Animal and Veterinary Sciences, 2010, 41(3): 341-346.

28.Ye Yuanlan, Li Yugu*, Wei Fengmei, Ma Yongjiang, Zhang Yuan, Jiang Qingyan. Localization, distributuion and development of Ghrelin-immunopositive neurons and influence of fasting on them in brains of broiler chickens[J]. Chinese Journal of Animal and Veterinary Sciences, 2010 , 41 (9): 1177-1184. 

29.Li Ying, Li Yugu*, Ye Yuanlan, Zhang Yuan, Ma Yongjiang. Localization, distribution and developmental expression of Ghrelin in thymus of BALB/c mice[J]. Chinese Journal of Animal and Veterinary Sciences, 2010, 41(8): 1024-1030 . 

30.Li Yugu, Zhang Yuan, Cui Congying. Pathology of chickens experimentally infected with a highly pathogenic avian influenza virus, A/duck/Guangdong/220/2004(H5N1)[J]. Journal of Jiangxi Agricultural University, 2010, 32(5): 860-867, 927. 

31.Li Ying, Zeng Jianwei, Pan Jiaqiang, Han Qiang, Li Yugu*. Establishment of ascites syndrome model by intravenous injection of cellulose particles[J]. Chinese Journal of Veterinary Sciences, 2011, 31(2): 245-248. 

32.Li Jiang, Yin Fan, Ma Yongjiang, Zhang Yuan, Li Ying, Li Yugu*. Inhibitory effect of Ghrelin on estrogen-induced thymocyte apoptosis in mice[J]. Chinese Journal of Veterinary Sciences, 2012, 32(5): 710- 714. 

33.Yin Fan, Li Jiang, Zhang Yuan, Ma Yongjiang, Li Ying, Li Yugu*. Effects of exogenous Ghrelin on the expression of cytokines and apoptosis-related protein genes during estrogen-induced thymus atrophy in mice[J]. Chinese Journal of Veterinary Sciences, 2012 , 32 (7): 1023-1027. 

34.Deng Haiying, Ye Yaqiong, Liu Jianhong, Yin Fan, Ma Yongjiang, Zhang Yuan, Li Ying, Li Yugu*. Reversal effect of exogenous Ghrelin on estrogen-induced thymus atrophy and changes of several thymic cytokine gene expressions in male mice[J]. Chinese Journal of Veterinary Sciences, 2013, 33(2): 206-211.

35.Tang Xiaohong, Ye Yaqiong, Li Daotong, Ma Haoran, Ouyang Dan, Chen Jian, Ma Yongjiang, Zhang Yuan, Li Yugu*. Isolation and identification of chicken adipose-derived mesenchymal stem cells[J]. Journal of South China Agricultural University, 2014, 35(5): 1-7. 

36.Zhou Heng, Shen Haiyan, Guo Pengju, Zhang Chunhong, Zhang Jianfeng, Liu Zhicheng, Sun Junying, Li Yugu*. Expression of recombinant porcine IFN-λ3 in E.coli and the anti-virus activity[J]. Chinese Journal of Veterinary Sciences, 2015, 35(1): 86- 90.

37.Chen Jian, Ye Yaqiong, Ouyang Dan, Ma Haoran, Ma Yongjiang, Zhang Yuan, Li Yugu*. Construction of eukaryotic expression plasmid with mouse Ghrelin protein gene and its effect on proliferation of 3T3-L1 preadipocytes[J]. Chinese Veterinary Sciences, 2015, 45 (12): 1300-1306. 

38.Zhang Lihua, Ouyang Dan, Xu Lifeng, Ma Yongjiang, Zhang Yuan, Li Yugu*. Effects of miR-92a-3p on proliferation and adipogenic differentiation of 3T3-L1 preadipocytes[J]. Chinese Veterinary Sciences, 2016, 46(11) :1450-1455.

39.Qi Junjie, Guo Dongguang, Tan Xiaotong, He Hui, Ma Yongjiang, Zhang Yuan, Li Yugu*. Effect of 17β-estradiol on proliferation of mouse thymic epithelial cells[J]. Chinese Journal of Veterinary Sciences, 2017, 37(10) :2004-2013. 

40.Xu Lifeng, Yu Xiaofang, Zhang Lihua, Ouyang Dan, Ma Yongjiang, Zhang Yuan, Li Yugu*. Effects of miR-23b-3p on proliferation and adipogenic differentiation of 3T3-L1 preadipocytes[J]. Chinese Journal of Veterinary Sciences, 2017, 37 (10): 2014-2019.

41.Tan Xiaotong, Liang Meile, Zhang Lihua, Xu Lifeng, Zhang Yuan, Ma Yongjiang, Li Yugu*. Effects of Ghrelin on proliferation and differentiation of chicken adipose-derived mesenchymal stem cells into adipocytes[J]. Chinese Journal of Veterinary Sciences, 2017, 37(5): 955-960. 

42.Liu Yameng, Li Zilong, Zhang Kaizhao, Guo Dongguang, Qi Junjie, Liang Guan, Ma Yongjiang, Li Yugu*. Effects of 17β-estradiol on proliferation and apoptosis of mouse thymic epithelial cells[J]. Chinese Journal of Veterinary Sciences, 2018, 48 (09): 1167-1175. 

43.Li YG, Zhou QH, Cui CY, Ye YL, Ma YJ, Zhang Y, Li CX. Histopathology of ducks experimentally infected with a highly pathogenic avian influenza virus A/duck/Guangdong/ 220/2004(H5N1)[J] . Chin J Anim Vet Sci, 2009, 40(S1): 67-77.

44.Lin SM, Li HM, Mu HP, Luo W, Li Y, Jia XZ, Wang SB, Jia XL, Nie QH, Li YG*, Zhang XQ*. Let-7b regulates the expression of the growth hormone receptor gene in deletion-type dwarf chickens [J]. BMC Genomics, 2012, 13: 306

45.Liu JH, Ma YJ, Li Ying, Peng HB, Li DT, Zhang Y, Li YG*. The expression analysis of ghrelin and growth hormone secretagogue receptor in mouse thymic epithelial cells[J]. J Anim Vet Adv, 2012, 11(16): 3027-3030. 

46.Ye Y, Lin S, Mu H, Tang X, Ouyang D, Chen J, Ma Y, Li Y*. Analysis of differentially expressed genes and signaling pathways related to intramuscular fat deposition in skeletal muscle of sex-linked dwarf chickens[J]. Biomed Res Int, 2014, 724274.

47.Ye Y, Li D, Ouyang D, Deng L, Zhang Y, Ma Y, Li Y*. microRNAs expression in the aging mouse thymus[J]. Gene, 2014, 547(2): 218-225. 

48.Ye Y, Deng L, Liang M, Xu L, Zhang L, Ma Y, Li Y*. microRNAs expression profiles in adipose tissues and liver from sex-linked dwarf and normal chickens[J]. Acta Biochim Biophys Sin, 2014, 46(8): 723-726.

49.Liu ZX, Ke H, Ma YP, Hao L, Feng GQ, Ma JY, Liang ZL, Li YG*. Oral Passive immunization of carp cyprinus carpio with anti-CyHV-3 chicken egg yolk immunoglobulin (IgY) [J]. Fish Pathol, 2014, 49(3): 113-120.

50.Ouyang D, Ye Y, Guo D, Yu X, Chen J, Qi J, Tan X, Zhang Y, Ma Y, Li Y*. microRNA-125b-5p inhibits proliferation and promotes adipogenic differentiation in 3T3-L1 preadipocytes[J]. Acta Biochim Biophys Sin, 2015, 47(5): 355-361.

51.Ouyang D, Xu L, Zhang L, Guo D, Tan X, Yu X, Qi J, Ye Y, Liu Q, Ma Y, Li Y*. microRNA-181a-5p regulates 3T3-L1 cell adipogenesis by targeting Smad7 and Tcf7l2[J]. Acta Biochim Biophys Sin, 2016, 48(11):1034-1041.

52.Guo D, Ye Y, Qi J, Xu L, Zhang L, Tan X, Tan Z, Yu X, Zhang Y, Ma Y, Li Y*. microRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7[J]. Acta Biochim Biophys Sin, 2016, 48(3):290-297. 

53.Guo D, Ye Y, Qi J, Zhang L, Xu L, Tan X, Yu X, Liu Q, Liu J, Zhang Y, Ma Y*, Li Y*. microRNA-181a-5p enhances cell proliferation in medullary thymic epithelial cells via regulating TGF-β signaling[J]. Acta Biochim Biophys Sin, 2016, 48(9):840-849. 

54.Ma YP, Ke H*, Liang ZL, Liu ZX, Hao L, Ma JY, Li YG*. Multiple evolutionary selections involved in synonymous codon usages in the streptococcus agalactiae genome[J]. Int J Mol Sci, 2016, 17(3):277.

55.Ma Y, Hao L, Ke H, Liang Z, Ma J, Liu Z*, Li Y*. LuxS/AI-2 in streptococcus agalactiae reveals a key role in acid tolerance and virulence[J]. Res Vet Sci, 2017, 115:501-507. 

56.Guo D, Ye Y, Qi J, Tan X, Zhang Y, Ma Y, Li Y*. Age and sex differences in microRNAs expression during the process of thymus aging[J]. Acta Biochim Biophys Sin, 2017, 49(5): 409-419. 

57.Lin S, Luo W, Ye Y, Bekele EJ, Nie Q, Li Y*, Zhang X*. Let-7b regulates myoblast proliferation by inhibiting IGF2BP3 expression in dwarf and normal chicken[J]. Front Physiol, 2017, 8:477. 

58.Wei C, Guo D, Li Y, Zhang K, Liang G, Li Y, Ma Y, Liu J*, Li Y*. Profiling analysis of 17β-estradiol-regulated lncRNAs in mouse thymic epithelial cells[J]. Physiol Genomics, 2018, 50(8):553-562. 

59.Zhang K, Tan X, Li Y, Liang G, Ning Z, Ma Y*, Li Y*.Transcriptional profiling analysis of Zearalenone-induced inhibition proliferation on mouse thymic epithelial cell line 1[J]. Ecotoxicol Environ Saf, 2018, 153:135-141. 

60.Jia HL, Zeng XQ, Huang F, Liu YM, Gong BS, Zhang KZ, Zeng JH, Guo DG, Wang ZY*, Li YG*. Integrated microRNA and mRNA sequencing analysis of age-related changes to mouse thymic epithelial cells[J]. IUBMB Life, 2018, 70(7): 678-690. 

Textbooks, monographs:

61.Wang Shuying, Wang Zhengfu, Li Yugu, et al. Animal Histology and Embryology. Beijing: China Agricultural Science and Technology Press, 2000.02, ISBN 7-80119-897-2

62.Luo Ke, Kang Shunzhi, Shen Yuanxin, Li Yugu, et al. Chinese Buffalo Organ Histology. Taiwan: Ruiyu Press, 2000.07, ISBN 957-8747-24-1

63.Li Yugu, et al. Anatomy and Physiology of Livestock, Poultry and Fish. Guangzhou: Guangdong Education Press, 2002.07, ISBN 7-5406-4785-X/G4377

64.Shen Xiafen, Li Yugu, et al. Livestock Histology and Embryology (Third Edition). Beijing: China Agriculture Press, 2002.09, ISBN7-109-06600-2

65.Yang Qian, Li Yugu, et al. Animal Histology and Embryology. Beijing: China Agricultural University Press, 2008.02, ISBN 978-7-81117-419-9

66.Shen Xiafen, Li Yugu, et al. Livestock Histology and Embryology (Fourth Edition). Beijing: China Agriculture Press, 2009.08, ISBN 978-7-109-13998-5

67.Peng Kemei, Li Yugu, et al. Animal Histology and Embryology. Beijing: Higher Education Press, 2009.08, ISBN 978-7-04-027653-4

68.Shen Xiafen, Qing Suzhu, Li Yugu, et al. Veterinary Histology and Embryology. Yang Ling: Northwest A&F University Press, 2009.10, ISBN 978-7-81092-467-2

69.Zhou Dinggang, Ma Hengdong, Li Yugu, et al. Livestock Anatomy and Physiology. Beijing: China Agriculture Press, 2010.05, ISBN 978-7-109-14400-2

70.Huang Ren, Tan Wenya, Cheng Shujun, Li Qingnan, Xu Jie, Li Yugu, et al. Rhesus Monkey Histology. Guangzhou: Guangdong Science and Technology Press, 2010.06, ISBN 978-7-5359-4857-1

71.Shen Xiafen, Qing Suzhu, Li Yugu, et al. Livestock Histology and Embryology (Fifth Edition). Beijing: China Agriculture Press, 2015.07, ISBN 978-7-109-20472-0

72.Peng Kemei, Wang Zhengfu, Li Yugu, et al. Animal Histology and Embryology Experiment (Color Version). Beijing: Higher Education Press, 2016.09, ISBN 978-7-04-046217-3

73.Peng Kemei, Li Yugu, et al. Animal Histology and Embryology (2nd Edition). Beijing: Higher Education Press, 2016.12, ISBN 978-7-04-045027-9

74.Yang Qian, Li Yugu, et al. Animal Histology and Embryology (Chinese-English Digital Textbook). Beijing: China Agricultural University Press, 2018.06, ISBN 978-7-5655-1959-8

75.Chen Qiusheng, Li Yugu, et al. Animal Histology and Embryology. Beijing: Science Press, 2018.06, ISBN 978-7-7-03-058376-5

To Students：

High buildings rise from the ground. A solid animal histology and embryology foundation is the ladder for you to the summit of animal and veterinary sciences. The microworld under the microscope is wonderful and mysterious. If you choose this research area, you can find the key to opening the door to the microworld as long as you work hard and study bravely.