1．IDENTITY OF THE CANDIDATE

a. Name: Xiaofeng Guo

b.Present position: Professor. College of Veterinary Medicine, South China Agricultural University

2.SPECIALIST COMMISSION OR WORKING GROUP THE CANDIDATE APPLIES FOR:

Scientific Commission for Animal Diseases

3.RELEVANT PROFESSIONAL EXPERIENCE

a. Developed a national standard on the diagnosis technology of duck virus enteritis.

b. Developed a new type of rabies vaccine carrying double glycoprotein genes.

4.EDUCATION AND PROFESSIONAL QUALIFICATIONS

a.1979-1984 South China Agricultural University, Bachelor Degree

b.1984-1987  Nanjing Agricultural University  Master Degree.

c.1997-2000  South China Agricultural University  Ph.D

d.2004=2005 University of Georgia, Postdoctor

5.PUBLICATIONS

Luo J, Zhang B, Wu Y, Tian Q, Mo M, Long T, Mei M, Fan R, Lyu Z, Jiang H, Wu F, Lin Y, Guo X. Recombinant rabies virus expressing interleukin-6 enhances the immune response in mouse brain. Arch Virol. 2018 Mar 28. doi: 10.1007/s00705-018-3808-8. [Epub ahead of print]

Qin Tian, Yifei Wang, Qiong Zhang, Jun Luo, He Jiang, Boyue Zhang, Mingzhu Mei, Fan Wu, YutingWu,JiaojiaoPeng, Teng Long, Yongwen Luo, Xiaofeng Guo .Phosphoprotein gene contributes to the enhanced apoptosis induced by wild-type rabies virus GD-SH-01 in vitro. Frontiers in Microbiology, 2017

（published: 05 September 2017 doi: 10.3389/fmicb.2017.01697）

Tian Q, Wang Y, Zhang Q, Luo J, Mei M, Luo Y, Guo XRescue of a wild-type rabies virus from cloned cDNA and assessment of the proliferative capacity of recombinant viruses. Virus Genes ,2017, 53(4):573–583

Mingzhu Mei, Teng Long,  Qiong Zhang, Jing Zhao, Qin Tian,  Jiaojiao Peng,  Jun Luo, Yifei Wang, Yingyi Lin and Xiaofeng Guo. Phenotypic Consequences In vivo and In vitro of Rearranging the P Gene of RABV HEP-Flury. Frontiers in Microbiology., 03 February 2017 

Xintian Zheng, Xiaoyan Yang, Xiaohua Li, Guo-Hua Qiu,Ailing Dai,Qichun Huang, Cuiqin Huang, Xiaofeng Guo. Omp16-based vaccine encapsulated by alginate-chitosan microspheres provides significant protection against Haemophilus parasuis in mice. Vaccine,2017(35)：1417-1423

Jun Luo, Boyue Zhang, Yuting Wu, Qin Tian, Jing Zhao, Ziyu Lyu, Qiong Zhang, Mingzhu Mei, Yongwen Luo, , Xiaofeng Guo. Expression of interleukin-6 by a recombinant rabies virus enhances its immunogenicity as a potential vaccine. Vaccine, 2017（35）：938-944

Jiaojiao Peng, Shenghe Zhu, Lili Hu, Pingping Ye, Yifei Wang, Qin Tian, Mingzhu Mei, Hao Chen & Xiaofeng Guo Wild-type rabies virus induces autophagy in human and mouse neuroblastoma cell lines.Autophagy, 2016,12(10):1704-1720

Jun Luo, Hehe Shi, Yeping Tan, Xuefeng Niu, Teng Long, Jing Zhao, Qin Tian, Yifei Wang, Hao Chen, Xiaofeng Guo. Two potential recombinant rabies vaccines expressing canine parvovirus virion protein 2 induce immunogenicity to canine parvovirus and rabies virus.Vaccine.Volume 34, Issue 37, 17 August 2016, Pages 4392–4398

Daiting Zhang, Feilong He, Shuilian Bi,  Huixia Guo, Baoshi Zhang, Fan Wu1Jiaqi Liang, Youtian Yang, Qin Tian,  Chunmei Ju, Huiying Fan, Jinding Chen, Xiaofeng Guo and Yongwen Luo. Genome-Wide Transcriptional Profiling Reveals Two Distinct Outcomes in Central Nervous System Infections of Rabies Virus, Frontiers in Microbiology, 2016,7

Jun Luo  Jing Zhao  Qin Tian Weiyu Mo Yifei Wang Hao Chen Xiaofeng Guo. A recombinant rabies virus carrying GFP between N and P affects viral transcription in vitro， Virus Genes (2016) 52(3):379–387

Yang Y, Liu W, Yan G, Luo Y, Zhao J, Yang X, Mei M, Wu X, Guo X. iTRAQ protein profile analysis of neuroblastoma (NA) cells infected with the rabies viruses rHep-Flury and Hep-dG. Front Microbiol. 2015 Jul 7;6:691. 

Yiping Zhu, Yongliang Huang, Yifei Wang, Keren Chen, Xuefeng Niu, Yongwen Luo, Xiaofeng Guo. Genome Sequence of a Canine Parvovirus Strain, CPV-s5, Prevalent in South China. Genome A, 2014,2(1):1

Simon Pierre Bahakoula, Xiaofeng Guo, Zhang Dongxia. Cloning and Expressing of the E Protein from West Nile Virus. International Journal of Science and Research, 2014,3(10):1450-1455

Yifei Wang, QinTian, XiaojuanXu, XianfengYang, JunLuo, WeiyuMo, _Jiaojiao Peng, XuefengNiu,YongwenLuo,XiaofengGuo. _Recombinant rabies virus expressing IFNα1 enhancedimmune responses resulting in its attenuation and stronger immunogenicity Virology 468-470(2014)621–630

Xian-Feng Yang, Jiao-Jiao Peng, Hong-Ru Liang, You-Tian Yang, Yi-Fei Wang,

Xiao-Wei Wu, Jiao-Jiao Pan, Yong-WenLuo & Xiao-Feng Guo. Gene order rearrangement of the M gene in the rabies virus leads to slower replication Virus Dis. 2014, 25(3):365–371

Liu X, Yang Y, Sun Z, Chen J, Ai J, Dun C, Fu ZF, Niu X, Guo X.A Recombinant Rabies Virus Encoding Two Copies of the Glycoprotein Gene Confers Protection in Dogs against a Virulent Challenge. PLoS One. 2014 ,9(2):1-10 

.Wu HX, Wang HL, Guo XF, Yang YJ, Ma JZ, Wang TC, Gao YW, Zhao YK, Yang ST, Xia XZ. Adeno-associated viruses serotype 2-mediated RNA interference efficiently inhibits rabies virus replication in vitro and in vivo. J Vet Med Sci. 2013 Oct;75(10):1355-61

Yongwen Luo , Ying Zhang , Xiangyin Liu, Youtian Yang, Xianfeng Yang, Zezhong     Zheng, Xianbo Deng,Xiaowei Wu, Xiaofeng Guo. Characterization of a wild rabies virus isolate of porcine origin in China,Infection Genetics and Evolution 17 (2013) 147–152

6.PROFESSIONAL MEMBERSHIP

a. Third National Veterinary Graduate Education Committee

b. National animal disease control experts committee, deputy head of the rabies expert team

c. Guangdong Animal Husbandry and Veterinary Medicine Committee, Deputy Secretary

d. Guangdong emergency management expert committee of major animal diseases, head of animal disease,

e. China Veterinary Microbiology Committee,

f. Narional Animal Inspection and Quarantine Standardization Committee

7.AWARDS

a. Guangdong Agricultural Technology Promotion Award, PCR Method for Detection of Rabies and Epidemiological Surveillance. 2010

b. Shennong Award Committee of Chinese Agricultural Science and Technology Award.Research Team of Zoonoses Prevention and Control.2008

c. Guangdong Provincial Government. Science and Technology Award. Research and Promotion of Avian influenza Inactivated Vaccine.2004.