Resume:

Jian-xin Chen，Male，Born in Dec 7th, 1967, Hunan province, Ph.D.in Natural medicinal chemistry, Professor. Member of Chinese Pharmaceutical Society, Vice Chairman of Guangdong Society for Mass Spectrometry. 

He received his Ph.D Degree in 2010 at College of Pharmacy, Jinan University (Guangzhou). During Sept. 2013 to Sept. 2014, he had been studied T cell immune induced by influenza virus infection at Prof. Weisan Chen’s lab, La Trobe University, Australia. He received professor position at South China Agricultural University in 2011. 

Since 2004, Jian-xin Chen has been doing his research in the development of antivirals. His research is currently focusing on discovery of novel antiviral compounds from traditional Chinese medicines and natural products against influenza viruses and porcine reproductive and respiratory syndrome viruses (PRRSV). His representative contribution is to discover the antiviral effect against influenza viruses infection of saikosaponin a and involved mechanismes. He has published more than 40 SCI papers including Oncotarget and JMC, totally been cited for more than 300 times. He had ever won the second prize of National Scientific and Technological Progress Award in 2005 and the first prize of Guangdong Scientific and Technological Progress Award in 2015 on account of contributions to the development of novel veterinary pharmaceutics.  

Education and Training Program: 

　　September, 2013-September, 2014: Visiting scholar, Department of

Biochemistry and Genetics, School of Molecular Science, La Trobe University,

Australia 

September, 2006-June, 2010: Ph.D., Biomedicine Engineering, College of Pharmacy , Jinan University, Guangzhou, China

September, 1995- June, 1998: M.S., Analytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China

September, 1985- June, 1989: B.S., Chemistry, Wuhan University, Wuhan, China

Working Experience: 

　　Novermber, 2011-Up to now: Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

June, 2003-October, 2011: Association Professor, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

July, 1990-May, 2003: Senior Researcher/Assistant Research Fellow, Institute of Animal Science, Guangdong Academy of Agricultural Sciences, Guangzhou, China

July, 1989-June, 1990: Assistant Engineer, Yangtang enterprise Co. LTD, Guangzhou, China

Research Interests:

Anti-inflammatory compounds from traditional Chinese medicines (TCM) and natural products

Antiviral compounds against (avian) influenza viruses from TCM and natural products

Antiviral compounds against porcine reproductive and respiratory syndrome viruses (PRRSV) from TCM and natural products

HPLC-MS analysis of TCM and natural products   

Undertaking Grants: 

A study on mechanisms of andrographolide and its derivates against PRRSV based on HO-1 and NF-κB signaling pathways, the National Natural Science Foundation, 2019-2022, 710,000 RMB, grant No: 31872521.

A study on structure-activity relationship and involved mechanisms of pentacyclic triterpenes against influenza viruses, the National Natural Science Foundation, 2016-2019, 750,000 RMB, grant No: 31572565.

Development of manufacturing technique and improvement of product quality of important veterinary drugs, the National Key R&D Program of China, 2017-2020, 983,000 RMB, grant No: 2017YFD0501404.

Recent Publications:

(1)Mingxin Zhang, Qianqian Wu, Yao Chen, Mubing Duan, Ge Tian, Xianbo Deng, Yankuo Sun, Tong Zhou, Guihong Zhang*, Weisan Chen*, Jianxin Chen*. Inhibition of proanthocyanidin A2 on porcine reproductive and respiratory syndrome virus replication in vitro. PLoS ONE, 2018, 13 (2): e0193309. 

(2)Jianxin Chen*，Mubing Duan，Yaqin Zhao, Fangfang Ling , Kun Xiao , Qian Li, Bin Li, Chunni Lu , Wenbao Qi , Zhenling Zeng , Ming Liao , Yahong Liu , Weisan Chen*, Saikosaponin A inhibits influenza A virus replication and lung immunopathology. Oncotarget, 2015, Vol. 6( 40):42541-42556

(3)Liping He, Yong Chen, Ziqiao Liang, Youzhi Li, Minglin Zhou, Zhiquan Yuan,Ling Luo, Zhen Jin, Yunyun Yang*, Jianxin Chen*. A rapid and comprehensive quality assessing method ofYin-Qiao-Jie-Du tablets using UHPLC-QTOF-MS in combination withmultivariate statistical analysis. Journal of Pharmaceutical and Biomedical Analysis 124 (2016) 129–137

(4)Qiuling Du, Jiewei Deng, Yahong Liu, Xiongwei Zhang, Yunyun Yang and Jianxin Chen*. Rapid assessing the quality of Qingkailing products using wooden-tip electrospray ionization mass spectrometry combined with multivariate statistical analysis. Analytical Methods. 2015, 7, 4803-4810

(5)Xiuxiu Chen, Hongxia Zhou, Wenbao Qi, Zhangyong Ning, Yongjiang Ma, Yaolan Li, Guocai Wang, Jianxin Chen*. Antiviral effects of the combination of glycyrrhizic acid and ribavirin against H1N1 influenza in vivo. Atca Pharmaceutica Sinica, 2015, 50(8):966-972 

(6)Jianhou Li, Fangfang Ling, Jinyan Du, Rongrong He, Yuanbo Li, Weimin Chen, Jianxin Chen*. Antiviral effects of the combination of baicalin and paramivir against H1N1 influenza in vitro and in vivo. Chinese Pharmacological Bulletin, 2013,29(5):617-621.

(7)Xiaokang Li, Wenbao Qi, Jun He, Zhangyong Ning, Yue Hu, Jin Tian, Peirong Jiao, Chenggang Xu, Jianxin Chen, Juergen Richt, Wenjun Ma, Ming. Liao*. Molecular Basis of Efficient Replication and Pathogenicity of H9N2 Avian Influenza Viruses in Mice [J]. PLoS ONE, 2012, 7(6):| e40118

(8)Huimin Cheng, Junting Wan, Meng-I Lin, Yingxue Liu, Xiaoyun Lu, Jinsong Liu, Yong Xu, Jianxin Chen, Zhengchao Tu, Yih-Shyun E. Cheng, and Ke Ding*. Design, Synthesis, and in Vitro Biological Evaluation of 1H-1,2,3-Triazole-4-carboxamide Derivatives as New Anti-influenza A Agents Targeting Virus Nucleoprotein [J]. J. Med. Chem. 2012, 55(5):2144-2153.

(9)Chun-Ni Lu, Zi-Guo Yuan, Xiao-Li Zhang, Ru Yan, Ya-Qin Zhao, Ming Liao, Jian-Xin Chen*. Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-κB signaling pathway [J]. Int Immunopharm. 2012, 14 (1) 121–126.

(10)Jian-Xin Chen, Jie-wei Deng, Hong Chen, Hai-yan Tian, Yun-yun Yang, Wen-cai Ye*. Identification of Bufadienolides and Its Metabolites in Rat Plasma by High Performance Liquid Chromatography coupled with LTQ-Orbitrap Mass Spectrometry [J]. Chinese J . Anal. Chem., 2011, 39(12): 1858-1863. 

(11)Zihua He, Yangjin Fu, Lanpin Wei, Rongrong He, Liyuan Bo, Yaozhi Yang, Jianxin Chen*. Antiviral effects of the combination of baicalin and ribavirin against influenza in vitro and in vivo. Chinese Pharmacological Bulletin, 2011,27(11):1560-1564. 

(12) Xuemeng Zhou, Chunni Lu, Wenbao Qi, Yongjiang Ma, Youzhi Tang, Jianxin Chen*. Antiviral effects of Qingkailing and Shuanghuanglian oral liquid against avian influenza viruses in vivo. Chinese Traditional and Herbal Drugs, 2011,42(7):1351-1355.

(13)Shenghui Huang, Youzhi Tang, Xuemeng Zhou, Guo Xie, Liyuan Bo, Zihua He, Jianxin Chen*. Antiviral effects of tea polyphenols against influenza viruses in vitro and in vivo. Journal of Tea Science, 2010, 30(4): 316-322.

(14) Rong-Rong He, Min Wang, Cong-Zhi Wang, Bang-Tian Chen, Chun-Ni Lu, Xin-Sheng Yao, Jian-Xin Chen*, and Hiroshi Kurihara*. Protective Effect of Apple Polyphenols against Stress-Provoked Influenza Viral Infection in Restraint Mice. J. Agric. Food Chem., 2011,59:3730–3737.

(15) Yun-Yun Yang, You-Zhi Tang, Chun-Lin Fan, Hui-Tai Luo, Peng-Ran Guo, Jian-Xin Chen*.   Identification and determination of the saikosaponins in Radix bupleuri by accelerated solvent extraction combined with rapid-resolution LC-MS. J. Sep. Sci. 2010, 33: 1933-1945.

(16) Jian-Xin Chen, Shen-Hui Huang, Lei Wang, Wei-Li Han, Ying Wang, and Wen-Cai Ye*. Two pairs of enantiomeric neolignans from Lobelia chinensis. Natural Product Communications, 2010, 5(10): 1627-1630.